Name of the Student Professor’s Name Toxicology-Coursework 10th January 2018 TUTORIAL 1 Compound A is a carboxylic acid with a pKa of 5.0. The protonated form of A has a partition coefficient of 1.0. If A is ingested, indicate a) its most likely site of absorption: stomach b) the effect of achlorhydria on the absorption: absorption is reduced c) the effect of administration of the compound immediately before and immediately after a substantial meal: before a meal, it is increased, but after a meal, it is reduced. 2. Why is insulin ineffective if given orally? Since insulin is a polypeptide hormone, it can be digested by proteases in the gastrointestinal tract. Hence,...
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